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name = Pennsylvania Name used in the default map caption; image = USA Pennsylvania location map.svg The default map image, without "Image:" or "File:" image1 = USA Pennsylvania relief location map.svg An alternative map image, usually a relief map, which can be displayed via the relief or AlternativeMap parameters; top = 42.7
A prolonged-release 2 mg oral formulation of melatonin sold under the brand name Circadin is approved for use in the European Union in the short-term treatment of insomnia in people age 55 and older. [11] [29] [8] Melatonin is also available as an over-the-counter dietary supplement in many countries. It is available in both immediate-release ...
α-Methylmelatonin, also known as α-methyl-5-methoxy-N-acetyltryptamine, is a synthetic tryptamine derivative and analogue of the monoamine neurotransmitter melatonin. [1] It is a metabolite of α-methyltryptophan, α-methyl-5-hydroxytryptophan, and α-methylserotonin that can be formed in small amounts via aralkylamine N-acetyltransferase (AANAT).
The United States Commonwealth of Pennsylvania currently has 48 statistical areas that have been delineated by the Office of Management and Budget (OMB). On July 21, 2023, the OMB delineated 12 combined statistical areas, 16 metropolitan statistical areas, and 20 micropolitan statistical areas in Pennsylvania. [1]
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Pennsylvania is one of 13 original colonies that share a border with Canada. Pennsylvania is 180 miles (290 km) north to south and 310 miles (500 km) east to west. The total land area is 44,817 square miles (116,080 km 2)—739,200 acres (2,991 km 2) of which are bodies of water. It is the 33rd largest state in the United States.
[1] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation. [2] Similar to melatonin, 6-OHM is a full agonist of the MT 1 and MT 2 receptors. [3] [4] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin. [5] [6]
Also a designated Reptile and Amphibian Protection Area. [18] [20] Carbaugh Run Natural Area: Michaux: Adams: 780 acres (316 ha) Also a designated Reptile and Amphibian Protection Area, and founded to protect Native American archeological sites. [13] [21] Charles F. Lewis Natural Area: Gallitzin: Indiana: 384 acres (155 ha) Named after an area ...