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  2. Selective estrogen receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_estrogen...

    The contact between the phenolic group, water molecule, and glutamate and arginine in the receptor (ERα; Glu 353/Arg 394) resolves in high affinity binding so that 4-hydroxy tamoxifen, with a phenolic ring that resembles the A ring of 17β-estradiol, has more than 100 times higher relative binding affinity than tamoxifen, which has no phenol.

  3. Steroidal aromatase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Steroidal_aromatase_inhibitor

    Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also ...

  4. Aromatase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Aromatase_inhibitor

    Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...

  5. Tamoxifen - Wikipedia

    en.wikipedia.org/wiki/Tamoxifen

    Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]

  6. What is Anastrozole? The breast cancer drug that can cut risk ...

    www.aol.com/news/anastrozole-breast-cancer-drug...

    Scientists have found that the hormone therapy - called anastrozole - can p revent women from developing breast cancer and that the protective effect lasts for years after the treatment has ended.

  7. Anastrozole - Wikipedia

    en.wikipedia.org/wiki/Anastrozole

    Anastrozole, sold under the brand name Arimidex among others, is an antiestrogenic medication used in addition to other treatments for breast cancer. [6] [7] Specifically it is used for hormone receptor-positive breast cancer. [7] It has also been used to prevent breast cancer in those at high risk. [7] It is taken by mouth. [7]

  8. Losing Weight vs. Losing Fat: What's the Difference? - AOL

    www.aol.com/losing-weight-vs-losing-fat...

    Let's first address weight loss. "Weight loss is the overall decrease in weight from all areas of the body," explains Annette Snyder, MS, RD, CSOWM, LD, from Top Nutrition Coaching. "This includes ...

  9. Non steroidal aromatase inhibitors - Wikipedia

    en.wikipedia.org/wiki/Non_steroidal_aromatase...

    A general letrozole pharmacophore model. Interaction between letrozole and amino acids in the binding site on the aromatase enzyme. 1,2,4 triazole ring binds to heme moiety. The cyano benzyl moiety is significant because it acts as carbonyl group of endogenous androstenedione.

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