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Somapacitan is the first human growth hormone (hGH) therapy that adults only take once a week by injection under the skin; other FDA-approved hGH formulations for adults with growth hormone deficiency must be administered daily. [10] It contains a small non-covalent moiety that reversibly binds to serum albumin which slows down elimination. [15]
At doses 20% higher than those used in GH deficiency, growth accelerates. With several years of treatment the median gain in adult height is about 5-8 cm on this dose. The gains appear to be dose-dependent. [14] It has been used successfully in toddlers with Turner syndrome, [15] as well as in older girls. [1] [2] [3] [16]
A recombinant form of HGH called somatropin is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider.
[9] [15] It may be appropriate in diagnosed adult-onset deficiency, where a weekly dose of approximately 25% of that given to children is given. Lower doses again are called for in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF-1.
Somatrem is a recombinant human growth hormone used for the treatment of short stature due to decreased or absent secretion of endogenous growth hormone.
Increase the dose in increments of 500 milligrams weekly or 850 milligrams every one to two weeks, up to a maximum dose of 2,550 milligrams per day, taken in divided doses.
Some of the side effects reportedly seen in previously healthy mature patients after taking high HGH doses include: Edema (retention of fluids) in extremities [14] Arthralgia (joint pain) [14] Carpal tunnel syndrome [14] Hypertension. [15] Diabetes and other glucose metabolism imbalances [14] Gynecomastia (enlargement of male mammary glands) [14]
An FDA-approved medication already used to treat people who have type 2 diabetes and chronic kidney disease may also help lower their stroke and heart attack risk, a new study has found.