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A lentigo (/ l ɛ n ˈ t aɪ ɡ oʊ /) (plural lentigines, / l ɛ n ˈ t ɪ dʒ ɪ n iː z /) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread.
Lentigo maligna is where melanocyte cells have become malignant and grow continuously along the stratum basale of the skin, [1] but have not invaded below the epidermis. [2] Lentigo maligna is not the same as lentigo maligna melanoma, as detailed below. It typically progresses very slowly and can remain in a non-invasive form for years.
Lentigo simplex is the most common form of lentigo. [ 2 ] : 29 A single lesion or multiple lesions (lentigines) may be present at birth or more commonly first develop in early childhood. Lentigo simplex is not induced by sun exposure, and it is not associated with any medical diseases or conditions.
Ink spot lentigo is a cutaneous condition characterized by skin lesions commonly occurring on the shoulders. [1] These lesions often cause alarm but are benign. They are an indication of excessive sun exposure so although ink spot lentigo is not premalignant, people with several of them maybe at increased risk of skin cancer due to UV damage.
Histology slide of a solar lentigo. Differently from the melanotic nevi and the verrucous nevi on the skin, age spots change in color and in shape with time. Wang-Michelitsch and Michelitsch propose a hypothesis inspired by their misrepair-accumulation aging theory [12] for the development of age spots. [13]
Lentiginosis refers to the presence of lentigines in large numbers or in a distinctive configuration. [1] These are spotted areas created by accumulation in the skin due to sun exposure.
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