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Endocarditis is an inflammation of the inner layer of the heart, the endocardium.It usually involves the heart valves.Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices.
However, if a heart valve is damaged, the bacteria can attach themselves to the valve, resulting in infective endocarditis. Additionally, in individuals with weakened immune systems, the concentration of bacteria in the blood can reach levels high enough to increase the probability that some will attach to the valve.
Alright, so to recap, endocarditis or inflammation of the endocardium typically develops from bacterial infection—usually in this case there’s first some damage or injury to the heart valves, which leads to thrombi which serves as a place for bacteria to adhere to and cause inflammation.
The main cause of endothelial dysfunction is impaired bioavailability of nitric oxide. [ 1 ] In addition to acting as a semipermeable membrane , the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin , and by controlling local ...
Heart failure can be a complication of any condition that causes damage to your heart tissues, such as an infection, heart attack, or valve disorder. Heart failure is categorized by a measurement ...
The heart is involved in about half of the cases. [1] Damage to the heart valves, known as rheumatic heart disease (RHD), usually occurs after repeated attacks but can sometimes occur after one. [1] The damaged valves may result in heart failure, atrial fibrillation and infection of the valves. [1]
Acutely, it can cause pericardial effusion leading to cardiac tamponade and death. After healing, there may be fibrosis and adhesion of the pericardium with the heart leading to constriction of the heart and reduced cardiac function. Myocarditis: Here the muscle bulk of the heart gets inflamed. Inflamed muscles have reduced functional capacity.
Eosinophilic myocarditis is inflammation in the heart muscle that is caused by the infiltration and destructive activity of a type of white blood cell, the eosinophil. Typically, the disorder is associated with hypereosinophilia , i.e. an eosinophil blood cell count greater than 1,500 per microliter (normal 100 to 400 per microliter).
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