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  2. Sertraline - Wikipedia

    en.wikipedia.org/wiki/Sertraline

    Following a single oral dose of sertraline, mean peak blood levels of sertraline occur between 4.5 and 8.4 hours. [5] Bioavailability is likely linear and dose-proportional over a dose range of 150 to 200 mg. [ 5 ] Concomitant intake of sertraline with food slightly increases sertraline peak levels and total exposure. [ 5 ]

  3. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]

  4. Serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor

    A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic ...

  5. Sertraline for Depression & Anxiety: What Are the Possible ...

    www.aol.com/sertraline-depression-anxiety...

    In comparative studies of sertraline and other SSRIs, about 14 percent of people who were prescribed sertraline at a typical dose experienced diarrhea, compared to about seven percent of those on ...

  6. Switching Antidepressants: Safety, Side Effects & Other ... - AOL

    www.aol.com/switching-antidepressants-safety...

    Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary between SSRIs. Effectiveness and side effect rates can vary ...

  7. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    The full mechanism of action for the anti-inflammatory effects of SSRIs is not fully known. However, there is evidence for various pathways to have a hand in the mechanism. One such possible mechanism is the increased levels of cyclic adenosine monophosphate (cAMP) as a result of interference with activation of protein kinase A (PKA), a cAMP ...

  8. Can Zoloft & Other SSRIs Cause "Intimate" Side Effects?

    www.aol.com/zoloft-other-ssris-cause-intimate...

    Adjusting your dosage of Zoloft. Zoloft is prescribed at several dosages, from 25mg to 200mg per day. Some side effects, including intimate effects, may be more common when Zoloft is used at a ...

  9. Development and discovery of SSRI drugs - Wikipedia

    en.wikipedia.org/wiki/Development_and_discovery...

    Sertraline is the second most potent inhibitor of 5-HT re-uptake which has two very interesting characteristics that distinguish it i.e. sertraline's (1) inhibiting effect on DAT and NET and (2) the binding to sigma-1 (σ 1) receptor in CNS. [18]

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