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Tucatinib, sold under the brand name Tukysa, is an anticancer medication used for the treatment of HER2-positive breast cancer. [ 3 ] [ 4 ] It is a small molecule inhibitor of HER2 . [ 6 ] [ 7 ] It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics ).
The Alliance seeks to reduce the impact of cancer on people by uniting a broad community of scientists and clinicians from many disciplines, committed to discovering, validating and disseminating effective strategies for the prevention and treatment of cancer. The Alliance conducts trials in the following disease and modality areas: breast ...
In pancreatic cancer. Dinaciclib inhibits pancreatic cancer growth and progression in murine xenograft models. [8] In osteosarcoma Dinacliclib induces the apoptosis of osteosarcoma cells. [9] Apoptosis of osteosarcoma cultures can be induced by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 ...
The efficacy and safety of pegulicianine were evaluated in a multicenter, intra-participant controlled clinical trial (NCT03686215) of participants with breast cancer undergoing lumpectomy surgery. [3] A total of 357 participants underwent image-guided surgery with the Lumicell DVS following standard of care lumpectomy. [3]
The Breast International Group’s purely academic research is supported in part by BIG against breast cancer, BIG’s the philanthropic unit. The funds raised by BIG against breast cancer go towards financing purely academic breast cancer trials and research conducted under the BIG umbrella.
Ribociclib (LEE011, trade names Kisqali and Kryxana), is US FDA approved in combination with letrozole for treatment of breast cancer in patients with HR-positive, HER2-negative advanced metastatic breast cancer. [16] A phase three clinical trial found that ribociclib administered in combination with letrozole increased the likelihood of ...
The DRKS is an open access, free of charge online register for clinical trials and is available both in English and German. DRKS is part of the WHO's ICTRP. The DRKS works with two partner registries in Germany, DeReG (German Registry for Somatic Gene-Transfer Trials) and Clinical Trial Registry of the University Medical Center Freiburg. [4]
A woman accessing the PDQ database with an early laptop in 1987. Physician Data Query (PDQ) is the US National Cancer Institute's (NCI) comprehensive cancer database. [1] [2] It contains peer-reviewed summaries on cancer treatment, screening, prevention, genetics, and supportive care, and complementary and alternative medicine; a registry of more than 6,000 open and 17,000 closed cancer ...
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