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After oral or intravenous administration, isavuconazonium is rapidly hydrolysed by esterases in blood or the gastrointestinal tract to the active form, isavuconazole. [7] [8] [15] Isavuconazole works by inhibition of lanosterol 14α-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation.
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
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Ravuconazole (codenamed BMS-207147 and ER-30346) is a potent triazole antifungal, the development of which was discontinued in 2007. [1] The drug has shown to have a similar spectrum of activity to voriconazole, with an increased half-life. [2]
Mark Cuban Cost Plus Drug Company (MCCPDC), doing business as Cost Plus Drugs, is an American public benefit corporation, founded in 2022 [1] with its main headquarters located in Dallas, Texas. The company is focused on the pharmacy distribution of drugs with a stated goal to lower the prices for generic drugs by removing middlemen, such as ...
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. [5] This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. [5]
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. [5]
Fosravuconazole (trade name Nailin) is a triazole antifungal agent. [1] [2] In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. [3]It is a prodrug that is converted into ravuconazole.
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