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Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. [5]
FDA-approved for treatment of myocardial infarction with ST-elevation (STEMI), acute ischemic stroke (AIS), acute massive pulmonary embolism, and central venous access devices (CVAD). [28] Reteplase: FDA-approved for acute myocardial infarction, where it has more convenient administration and faster thrombolysis than alteplase. This is because ...
More than 795,000 people in the U.S. have a stroke each year, which is a leading cause of serious long-term disability. Many of the leading risk factors for stroke are modifiable, making ...
The Joint Commission defines a Primary Stroke Center as follows: "This program is designed for hospitals providing the critical elements to achieve long-term success in improving outcomes for stroke patients." [16] Primary stroke centers have "acute stroke teams" [13] as recommended by the Brain Attack Coalition. The centers should have a ...
The American Heart Association/American Stroke Association (AHA/ASA) recommends controlling these risk factors in order to prevent stroke. [15] The AHA/ASA guidelines also provide information on how to prevent stroke if someone has more specific concerns, such as sickle-cell disease or pregnancy. It is also possible to calculate the risk of ...
The National Institutes of Health Stroke Scale, or NIH Stroke Scale (NIHSS), is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke and aid planning post-acute care disposition, though was intended to assess differences in interventions in clinical trials. The NIHSS was designed for the National ...
National Stroke Association was formed in 1984 as a nonprofit healthcare organization focusing 100 percent of its resources on stroke. The organization is based in Centennial, Colorado. [1] In 2006, the Annals of Neurology published National Stroke Association’s guidelines for the management of transient ischemic attacks.
Bederson JB, Chair, Awad I, Rosenwasser R, Weibers D, Piepgras D, Hademenos G, Members. "Guidelines for the management of unruptured intracranial aneurysms. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association." Stroke, 2000, 31, 2742–2750. PMID 11056108