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Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications.
Aminoglutethimide has an oral administration and a usual dosage range between 250 and 100 mg/day. The drug has good oral bioavailability , it absorbs rapidly and completely. Aminoglutethimide has a good distribution around the body and is partly metabolized in the liver by acetylation .
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide.
These drugs include aminoglutethimide, ketoconazole, [151] and abiraterone acetate. [ 89 ] [ 31 ] [ 152 ] Aminoglutethimide inhibits cholesterol side-chain cleavage enzyme, also known as P450scc or CYP11A1, which is responsible for the conversion of cholesterol into pregnenolone and by extension the production of all steroid hormones, including ...
Glutethimide is a Schedule II drug under the Convention on Psychotropic Substances. [10] It was originally a Schedule III drug in the United States under the Controlled Substances Act, but in 1991 it was upgraded to Schedule II, [11] several years after it was discovered that misuse combined with codeine increased the effect of the codeine and deaths had resulted from the combination.
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
The aromatase inhibitor aminoglutethimide induces the metabolism of tamoxifen. [5] Conversely, the aromatase inhibitor letrozole does not affect the metabolism of tamoxifen. [5] However, tamoxifen induces the metabolism of letrozole and significantly reduces its concentrations. [5]
Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer.It is a member of the class of antiestrogens known as aromatase inhibitors.