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Thiocyanate [6] is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. [7] [8] [9] Thus the complete absence of thiocyanate or reduced thiocyanate [10] in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system.
In methyl thiocyanate, N≡C and C−S distances are 116 and 176 pm. By contrast, N=C and C=S distances are 117 and 158 pm in isothiocyanates. [7] Typical bond angles for C−S−C are 100°. [3] By contrast C−N=C in aryl isothiocyanates is 165°. Again, the thiocyanate isomers are quite different with C−S−C angle near 100°.
By contrast, in methyl thiocyanate, N≡C and C−S distances are 116 and 176 pm. Typical bond angles for C−N=C in aryl isothiocyanates are near 165°. Again, the thiocyanate isomers are quite different with C−S−C angle near 100°. [3] In both isomers the SCN angle approaches 180°.
Thiocyanate can bind metals at either sulfur or nitrogen — it is an ambidentate ligand. Other factors, e.g. kinetics and solubility, sometimes influence the observed isomer. For example, [Co(NH 3) 5 (NCS)] 2+ is the thermodynamic isomer, but [Co(NH 3) 5 (SCN)] 2+ forms as the kinetic product of the reaction of thiocyanate salts with [Co(NH 3 ...
In chemistry, linkage isomerism or ambidentate isomerism is a form of isomerism in which certain coordination compounds have the same composition but differ in their metal atom's connectivity to a ligand. Typical ligands that give rise to linkage isomers are: cyanide, CN − – isocyanide, NC −; cyanate, OCN − – isocyanate, NCO −
Sodium thiocyanate (sometimes called sodium sulphocyanide) is the chemical compound with the formula NaSCN. This colorless deliquescent salt is one of the main sources of the thiocyanate anion . As such, it is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals . [ 2 ]
Fluorescein isothiocyanate (FITC) is a derivative of fluorescein used in wide-ranging applications [1] [2] including flow cytometry.First described in 1942, [3] FITC is the original fluorescein molecule functionalized with an isothiocyanate reactive group (−N=C=S), replacing a hydrogen atom on the bottom ring of the structure.
Hypothiocyanite is the anion [OSCN] − and the conjugate base of hypothiocyanous acid (HOSCN). It is an organic compound part of the thiocyanates as it contains the functional group SCN. It is formed when an oxygen is singly bonded to the thiocyanate group. Hypothiocyanous acid is a fairly weak acid; its acid dissociation constant (pK a) is 5.3.