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In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy. And there is an indication that phosphonate derivatives are "promising ligands for nuclear medicine." [2]
Phosphonates are esters of phosphonic acid and have the general formula RP(=O)(OR') 2. Phosphonates have many technical applications, a well-known member being glyphosate, better known as Roundup. With the formula (HO) 2 P(O)CH 2 NHCH 2 CO 2 H, this derivative of glycine is one of the most widely used herbicides.
Category: Phosphonic acids and derivatives. 4 languages. ... Phosphonates (2 C, 6 P) Phosphonic acids (1 C, 40 P) Phosphonofluoridates (2 C, 2 P) Phosphonothioates (12 P)
Phosphonates are salts (M 2 HPO 3) or esters (OP(OR) 2 R) of phosphonic acid Subcategories. This category has the following 2 subcategories, out of 2 total. P ...
This nomenclature is commonly reserved for substituted derivatives, that is, organic group bonded to phosphorus, not simply an ester. For example, (CH 3 )PO(OH) 2 is " methylphosphonic acid ", which may of course form "methyl phosphonate " esters .
Nucleoside phosphoramidites are derivatives of natural or synthetic nucleosides. ... the product is an H-phosphonate diester as shown in Scheme above. Due to the ...
Aminophosphonates are often prepared by hydrophosphonylation, usually the condensation of imines and phosphorous acid.In the Pudovik reaction or Kabachnik–Fields reaction the esters of phosphorous acid are employed, e.g. diphenylphosphite.
Although they are derivatives of phosphonous acid (RP(OH) 2), [2] they are not prepared from such precursors. Phosphonites are prepared by alcoholysis of organophosphinous chlorides. For example, treatment of dichlorophenylphosphine with methanol and base gives dimethyl phenylphosphonite: