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In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy. And there is an indication that phosphonate derivatives are "promising ligands for nuclear medicine." [2]
Phosphonate esters (18 P) Pages in category "Phosphonates" The following 6 pages are in this category, out of 6 total. This list may not reflect recent changes. *
3 (phosphonate) groups covalently linked to carbon determine both the name "bisphosphonate" and the function of the drugs. Bis refers to the fact that there are two such groups in the molecule. The long side-chain (R 2 in the diagram) determines the chemical properties, the mode of action and the strength of bisphosphonate drugs.
Structural formula of Na 2 HPO 3.The anion has C 3v symmetry.. From the commercial perspective, the most important phosphite salt is basic lead phosphite.Many salts containing the phosphite ion have been investigated structurally, these include sodium phosphite pentahydrate (Na 2 HPO 3 ·5H 2 O).
Organophosphorus chemistry is the scientific study of the synthesis and properties of organophosphorus compounds, which are organic compounds containing phosphorus. [1] They are used primarily in pest control as an alternative to chlorinated hydrocarbons that persist in the environment.
In 1977 the United States Environmental Protection Agency published a position paper advocating for a phosphate ban in detergents.. States including Maine, Florida, and Indiana in the United States began restricting or banning the use of phosphates in laundry detergent in the early 1970s, culminating in a nationwide voluntary ban in 1994. [3]
The Horner–Wadsworth–Emmons (HWE) reaction is a chemical reaction used in organic chemistry of stabilized phosphonate carbanions with aldehydes (or ketones) to produce predominantly E-alkenes. [1] The Horner–Wadsworth–Emmons reaction. In 1958, Leopold Horner published a modified Wittig reaction using phosphonate-stabilized carbanions.
Phosphate is an inorganic chemical and a salt-forming anion of phosphoric acid, commonly found in fertilizers.