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A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
The instrument detection limit (IDL) is the analyte concentration that is required to produce a signal greater than three times the standard deviation of the noise level. This may be practically measured by analyzing 8 or more standards at the estimated IDL then calculating the standard deviation from the measured concentrations of those standards.
In a primary screen without replicates, assuming the measured value (usually on the log scale) in a well for a tested compound is and the negative reference in that plate has sample size , sample mean ¯, median ~, standard deviation and median absolute deviation ~, the SSMD for this compound is estimated as [20] [23]
A tolerance interval (TI) is a statistical interval within which, with some confidence level, a specified sampled proportion of a population falls. "More specifically, a 100×p%/100×(1−α) tolerance interval provides limits within which at least a certain proportion (p) of the population falls with a given level of confidence (1−α)."
Since the sample mean and variance are independent, and the sum of normally distributed variables is also normal, we get that: ^ + ˙ (+, + ()) Based on the above, standard confidence intervals for + can be constructed (using a Pivotal quantity) as: ^ + + And since confidence intervals are preserved for monotonic transformations, we get that
In statistics and econometrics, the mean log deviation (MLD) is a measure of income inequality. The MLD is zero when everyone has the same income, and takes larger ...
It is usually determined on the basis of the cost, time or convenience of data collection and the need for sufficient statistical power. For example, if a proportion is being estimated, one may wish to have the 95% confidence interval be less than 0.06 units wide. Alternatively, sample size may be assessed based on the power of a hypothesis ...
The R-chart shows sample ranges (difference between the largest and the smallest values in the sample), while the s-chart shows the samples' standard deviation. The R-chart was preferred in times when calculations were performed manually, as the range is far easier to calculate than the standard deviation; with the advent of computers, ease of ...