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Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis , blastomycosis , coccidioidomycosis , cryptococcosis , histoplasmosis , dermatophytosis , and tinea versicolor . [ 5 ]
Some fungi (e.g. Candida krusei and fluconazole) exhibit intrinsic resistance to certain antifungal drugs or classes, whereas some species develop antifungal resistance to external pressures. Antifungal resistance is a One Health concern, driven by multiple extrinsic factors, including extensive fungicidal use, overuse of clinical antifungals ...
In most cases, the diagnosis is established based on response to therapy. Patients in whom esophageal candidiasis is suspected should receive a brief course of antifungal therapy with fluconazole. If the infection resolves after treatment with fluconazole, then the diagnosis of esophageal candidiasis is made and no further investigation is needed.
Candidiasis is a fungal infection due to any species of the genus Candida (a yeast). [4] When it affects the mouth, in some countries it is commonly called thrush. [3] Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. [3]
Candida dubliniensis is cosmopolitan (found around the world), and has been described as a separate species in 1995. [2] Retrospective studies have shown that previously it had been commonly identified as Candida albicans, with which C. dubliniensis is closely related and shares a number of characteristics.
Posaconazole is absorbed within three to five hours. It is predominantly eliminated through the liver, and has a half-life of about 35 hours. Oral administration of posaconazole taken with a high-fat meal exceeds 90% bioavailability and increases the concentration by four times compared to fasting state.
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This may be either as a cream such as clotrimazole or with oral medications such as fluconazole. [4] Despite the lack of evidence, wearing cotton underwear and loose fitting clothing is often recommended as a preventive measure. [1] [2] Avoiding douching and scented hygiene products is also recommended. [1]
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