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Because they commonly involve more than one gene, the disorders caused by these large deletion and duplication mutations are often severe.
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution. It can be defined as any duplication of a region of DNA that contains a gene.
Duplication is a type of structural mutation where a part of a chromosome is present in excess of the normal composition. The genes present in a cell might exist in more than two doses as a result of duplication.
Duplication is a type of mutation that involves the production of one or more copies of a gene or region of a chromosome.
Gene duplication occurs when a mutation in a chromosome results in an extra copy of a specific genomic segment, including the entire gene. This duplication can be an advantageous event for an organism as it provides an opportunity for genetic variation and innovation.
Usually, a chromosomal mutation happens because of a change in chromosome structures, chromosomal rearrangement, or other chromosomal abnormalities such as a change in chromosome number or missing chromosome.
Duplications also produce a cytologically visible loop at meiotic pairing. Duplications can revert at a relatively high frequency by unequal crossing over. Duplicated genes offer new possibilities for mutational divergence followed by natural selection in the course of evolution.
Duplications: A portion of the chromosome is duplicated, resulting in extra genetic material. Translocations: A portion of one chromosome is transferred to another chromosome. There are two main types of translocation.
Gene duplications create genetic redudancy and can have various effects, including detrimental mutations or divergent evolution.
Mutations can also influence the phenotype of an organism. This tutorial looks at the effects of chromosomal mutations, such as nondisjunction, deletion, and duplication.