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The T max of doxylamine is 1.5 to 2.5 hours. [2] Its elimination half-life is 10 to 12 hours (range 7 to 15 hours). [2] [3] [4] Doxylamine is metabolized in the liver primarily by the cytochrome P450 enzymes CYP2D6, CYP1A2, and CYP2C9. [2] [40] The main metabolites are N-desmethyldoxylamine, N,N-didesmethyldoxylamine, and doxylamine N-oxide. [41]
Carpal tunnel syndrome – Carpal tunnel syndrome can occur in up to 70% of pregnant women and typically has a benign course. [16][17] It manifests as pain, numbness, and tingling in the thumb, index finger, middle finger and the thumb side of the ring finger. [18] The symptoms of carpal tunnel syndrome during pregnancy are usually mild and do ...
Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. [ 1 ] Despite the name, nausea or vomiting can occur at any time during the day. [ 2 ] Typically the symptoms occur between the 4th and 16th week of pregnancy. [ 2 ]
Previous studies have suggested sickness and nausea in pregnancy could relate to GDF15 being produced by the placenta, but researchers said the “full mechanistic understanding is lacking”.
Postorgasmic illness syndrome. Postorgasmic illness syndrome (POIS) is a syndrome in which human males have chronic physical and cognitive symptoms following ejaculation. [1] The symptoms usually onset within seconds, minutes, or hours, and last for up to a week. [1] The cause and prevalence are unknown; [2] it is considered a rare disease.
Scientists are moving forward with researching cures for morning sickness, including testing drugs that block GDF15 from binding to its receptor in the brain, and exposing women to the hormone ...
Metal fume fever, also known as brass founders' ague, brass shakes, [1] zinc shakes, galvie flu, galvo poisoning, metal dust fever, welding shivers, or Monday morning fever, [2] is an illness primarily caused by exposure to chemicals such as zinc oxide (ZnO), aluminium oxide (Al 2 O 3), or magnesium oxide (MgO) which are produced as byproducts in the fumes that result when certain metals are ...
50 First Dates. 50 First Dates is a 2004 American romantic comedy film directed by Peter Segal and starring Adam Sandler and Drew Barrymore, with Rob Schneider, Sean Astin, Lusia Strus, Blake Clark, and Dan Aykroyd in supporting roles. It follows the story of Henry Roth, a womanizing marine veterinarian who falls for an art teacher named Lucy ...
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