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Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels in type 2 diabetes patients. It reduces glucose absorption from the intestines, lowers liver glucose production, and improves insulin sensitivity. Metformin is recommended with dietary changes and exercise for better results.
Identify the approved and off-label indications for metformin use, such as type 2 diabetes, prediabetes, gestational diabetes, antipsychotic-induced weight gain, and PCOS. Differentiate the various drug-drug interactions associated with metformin, identifying their clinical presentations.
Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis), decreasing the intestinal absorption of glucose, and increasing insulin sensitivity by increasing peripheral glucose uptake and utilization. 23 It is well established that metformin inhibits mitochondrial complex I activity, and it ...
Metformin hydrochloride tablets are a biguanide indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. ( 1) Adult Dosage for Metformin Hydrochloride Tablets: Pediatric Dosage for Metformin Hydrochloride Tablets: Renal Impairment:
Using metformin alone, with a type of oral antidiabetic medicine called a sulfonylurea, or with insulin, will help to lower blood sugar when it is too high and help restore the way you use food to make energy. Many people can control type 2 diabetes with diet and exercise.
Metformin currently plays a central role in the treatment of type 2 diabetes and may also have benefits in other pathologies. Although it is generally considered to have a good safety profile, some precautions are essential for its correct use.
Metformin or dimethyl biguanide is the oral antidiabetic drug with the most extensive experience of prescribing in the clinical practice of type 2 diabetes mellitus. In this chapter, we reviewed the indications, contraindications, and adverse drug reactions (ADR) of metformin.
Metformin is used to help lower blood sugar levels in people with type 2 diabetes. Metformin may also be used for other conditions as determined by your healthcare provider.
Metformin is the preferred therapy for people with Type 2 diabetes without any contraindications. It may be used in combination with other medications for Type 2 diabetes. May be used off-label (not an FDA-approved use, but still a recognized use of the drug) in polycystic ovary syndrome.
Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood.