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Raxibacumab [2] is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax.Its efficacy has been proven in rabbits and monkeys. [3] In December 2012 raxibacumab was approved in the United States for the treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs, and for prophylaxis of inhalational anthrax ...
Anthrax is an infection caused by the bacterium Bacillus anthracis or Bacillus cereus biovar anthracis. [2] Infection typically occurs by contact with the skin, inhalation, or intestinal absorption. [9] Symptom onset occurs between one day and more than two months after the infection is contracted. [1]
B. anthracis endospores, in particular, are highly resilient, surviving extremes of temperature, low-nutrient environments, and harsh chemical treatment over decades or centuries. [citation needed] The endospore is a dehydrated cell with thick walls and additional layers that form inside the cell membrane.
Anthrax weaponization is the development and deployment of the bacterium Bacillus anthracis or, more commonly, its spore (referred to as anthrax), as a biological weapon.As a biological weapon, anthrax has been used in biowarfare and bioterrorism since 1914. [1]
Treatment Prevention Actinomyces israelii: Oral flora [48] Actinomycosis: [48] painful abscesses and cysts MRSA in the mouth, lungs, [49] [50] or gastrointestinal tract. [35] Prolonged penicillin G and drainage [48] Bacillus anthracis: Contact with cattle, sheep, goats and horses [51] Spores enter through inhalation or through abrasions [33]
The Sterne strain, like all Bacillus anthracis strains, has two functional 𝛃-lactamases, but gene expression is usually not sufficient to allow drug resistance. The Sterne strain acts as a good comparison to other anthrax strains, as it is a prototypical and easy to work with strain, with sensitivity to penicillin.
A widened use of the broad-spectrum antibiotic ciprofloxacin had also raised serious concerns amongst scientists about the creation and increased spread of drug-resistant bacteria strains. [173] Numerous corporations offered to supply drugs free of charge, contingent on the Food and Drug Administration approving their products for anthrax ...
Anthrax is a disease caused by Bacillus anthracis, a spore-forming, Gram positive, rod-shaped bacterium (Fig. 1).The lethality of the disease is caused by the bacterium's two principal virulence factors: (i) the polyglutamic acid capsule, which is anti-phagocytic, and (ii) the tripartite protein toxin, called anthrax toxin.