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For example, the p53 knockout mouse is named after the p53 gene which codes for a protein that normally suppresses the growth of tumours by arresting cell division and/or inducing apoptosis. Humans born with mutations that deactivate the p53 gene have Li-Fraumeni syndrome , a condition that dramatically increases the risk of developing bone ...
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to create knockout mice to study.
A conditional gene knockout allows gene deletion in a tissue in a tissue specific manner. This is required in place of a gene knockout if the null mutation would lead to embryonic death, [13] or a specific tissue or cell type is of specific interest. This is done by introducing short sequences called loxP sites around the gene.
The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.
MGI provides access to data on the genetics, genomics and biology of the laboratory mouse to facilitate the study of human health and disease. [2] [3] The database integrates multiple projects, with the two largest contributions coming from the Mouse Genome Database and Mouse Gene Expression Database (GXD). [4]
The Mouse Genetics Project (MGP) is a large-scale mutant mouse production and phenotyping programme aimed at identifying new model organisms of disease. [1] [2] [3] [4]Based at the Wellcome Trust Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium.
selecting the stem cell (with the appropriate mutant gene) from the EUCOMM library and then; breeding a knockout mouse from that ES Cell (see Knockout mouse) The broad aim of the project is to facilitate research into gene function in mice (and so by inference in humans) by removing the high technical entry barrier of making the mutant ES Cells.
Knockout mice, where a specific gene was made inoperable by a technique known as gene knockout: the purpose is to study the function of the gene's product or to simulate a human disease Fat mice, prone to obesity due to a carboxypeptidase E deficiency; Strong muscular mice, with a disabled myostatin gene, nicknamed "mighty mice".
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