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Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [4] [5] and in 2012, for cats. [6]
Newer rodenticides may contain bromethalin which causes central nervous system signs such as seizures, muscle tremors, and depression. [176] Insecticides* used in dogs for fleas and ticks commonly contain either organophosphates or carbamates. They can be absorbed through the skin, conjunctiva, gastrointestinal tract, and lungs.
The minimum lethal dose in dogs is over 5 mg/m 2; dogs have tolerated getting ten times the standard dose. [ 9 ] [ 33 ] Signs of overdose include panting, trembling, vomiting, and diarrhea, as well as increased blood levels of creatine kinase , aspartate transaminase , and alanine transaminase .
Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats.It is a form of meningoencephalitis.GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. [1]
However, the mean terminal half-life elimination for young volunteer subjects administered 75 mg cinnarizine, was found to be 23.6 ± 3.2 hours. [ 2 ] A study that administered 75 mg doses of cinnarizine, twice a day for twelve days, to healthy volunteers, observed that cinnarizine did accumulate in the body, with a steady-state accumulation ...
Canine distemper virus (CDV) (sometimes termed "footpad disease") is a viral disease that affects a wide variety of mammal families, [2] including domestic and wild species of dogs, coyotes, foxes, pandas, wolves, ferrets, skunks, raccoons, and felines, as well as pinnipeds, some primates, and a variety of other species.
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