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The parasympathetic nervous system, via the vagus nerve, and the hormone gastrin stimulate the parietal cell to produce gastric acid, both directly acting on parietal cells and indirectly, through the stimulation of the secretion of the hormone histamine from enterochromaffin-like cells (ECLs).
Acid in small intestine Gastric inhibitory Peptide: Endocrine K cells of the small intestine Beta cells of the pancreas Stimulates pancreatic insulin release Inhibits acid secretion None Satiety and lipid metabolism Glucose, fatty acid, and amino acids in small intestine Motilin: Endocrine M cells in small intestine Smooth muscle of stomach and ...
It can also be stimulated by a pH of 3-4 in the duodenum and by a pH of 1.5 in the stomach. Upon initiation of the reflex, the release of gastrin by G-cells in the antrum of the stomach is shut off. This in turn inhibits gastric motility and the secretion of gastric acid . [1]
3) In the antrum, peptidergic postganglionic parasympathetic vagal neurons and other enteric nervous system neurons release GRP which stimulates antral G cells to produce and release gastrin. Gastrin stimulates gastric acid secretion by directly stimulating parietal cells as well as by promoting histamine secretion by ECL cells.
Vagotomy was a way to reduce the acidity of the stomach, by denervating the parietal cells that produce acid. This was done with the hope that it would treat or prevent peptic ulcers. It also had the effect of reducing or eliminating symptoms of gastroesophageal reflux in those who suffered from it.
Gastrin-releasing peptide is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. [10] The post-ganglionic fibers of the vagus nerve that innervate bombesin/GRP neurons of the stomach release GRP, which stimulates the G cells to release gastrin.
A G cell or gastrin cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells. G cells are found deep within the pyloric glands of the stomach antrum, and occasionally in the pancreas [1] and duodenum. The vagus nerve innervates the G cells.
The myenteric plexus (or Auerbach's plexus) provides motor innervation to both layers of the muscular layer of the gut, having both parasympathetic and sympathetic input (although present ganglion cell bodies belong to parasympathetic innervation, fibers from sympathetic innervation also reach the plexus), whereas the submucous plexus provides secretomotor innervation to the mucosa nearest the ...
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