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The Zerewitinoff determination or Zerevitinov determination is a quantitative chemical test for the determination of active hydrogens in a chemical substance [1] developed by F. V. Tserevitinov [] (jointly with L. A. Chugaev) in 1902-1907.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
As a chiral derivatizing agent, it reacts with an alcohol or amine [5] of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19 F NMR spectroscopy. Mosher's acid chloride, the acid chloride form, is sometimes used because it has better reactivity. [6]
Once this is determined, all one needs to do is take the total value of Δ f H, subtract the Δ f H caused by the C−(C) 2 (H) 2 group(s), and then divide that number by two (due to two C−(C)(H) 3 groups), obtaining the value of the C−(C)(H) 3 group. From the knowledge of these two groups, Benson moved forward obtain and list functional ...
The ion is selected in the second mass spectrometry stage MS2 then undergoes further fragmentation to form ion D + which is selected in the third mass spectrometry stage MS3 and detected. Multiple reaction monitoring ( MRM ) is the application of selected reaction monitoring to multiple product ions from one or more precursor ions, [ 3 ] [ 4 ...
Classical qualitative inorganic analysis is a method of analytical chemistry which seeks to find the elemental composition of inorganic compounds.It is mainly focused on detecting ions in an aqueous solution, therefore materials in other forms may need to be brought to this state before using standard methods.
In analytical chemistry, sample preparation (working-up) refers to the ways in which a sample is treated prior to its analyses. Preparation is a very important step in most analytical techniques, because the techniques are often not responsive to the analyte in its in-situ form, or the results are distorted by interfering species.
The bond valence method or mean method (or bond valence sum) (not to be mistaken for the valence bond theory in quantum chemistry) is a popular method in coordination chemistry to estimate the oxidation states of atoms. It is derived from the bond valence model, which is a simple yet robust model for validating chemical structures with ...