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At an evolutionary level, this stabilization of oxygen levels, which also results in a more constant carbon dioxide concentration and pH, was important to manage oxygen flow in air-vs.-water breathing, sleep, and to maintain an ideal pH for protein structure, since fluctuations in pH can denature a cell's enzymes.
The carotid body is situated on the posterior aspect of the bifurcation of the common carotid artery. [3]The carotid body is made up of two types of cells, called glomus cells: glomus type I cells are peripheral chemoreceptors, and glomus type II cells are sustentacular supportive cells.
Peripheral chemoreceptors (carotid and aortic bodies) and central chemoreceptors (medullary neurons) primarily function to regulate respiratory activity. This is an important mechanism for maintaining arterial blood pO2, pCO2 , and pH within appropriate physiological ranges.
Blood levels of oxygen become important in hypoxia. These levels are sensed by central chemoreceptors on the surface of the medulla oblongata for decreased pH (indirectly from the increase of carbon dioxide in cerebrospinal fluid ), and the peripheral chemoreceptors in the arterial blood for oxygen and carbon dioxide.
The kidneys measure the oxygen content rather than the partial pressure of oxygen in the arterial blood. When the oxygen content of the blood is chronically low, oxygen-sensitive cells secrete erythropoietin (EPO) into the blood. [53] The effector tissue is the red bone marrow which produces red blood cells (RBCs, also called erythrocytes).
This modulation of synaptic transmission and electrical discharge at the cellular level is due to BK channel expression in conjunction with other potassium-calcium channels. [10] The opening of these channels causes a drive towards the potassium equilibrium potential and thus play a role in speeding up the repolarization of action potentials. [10]
Pulmonary (lung) circulation undergoes hypoxic vasoconstriction, which is a unique mechanism of local regulation in that the blood vessels in this organ react to hypoxemia, or low levels of dissolved oxygen in blood, in the opposite way as the rest of the body. While tissues and organs tend to increase blood flow by vasodilating in response to ...
Potassium resides mainly inside the cells of the body, so its concentration in the blood can range anywhere from 3.5 mEq/L to 5 mEq/L. [14] The kidneys are responsible for excreting the majority of potassium from the body. [14] This means their function is crucial for maintaining a proper balance of potassium in the blood stream.
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