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And it matters, because although Zyrtec (the brand name for cetirizine) and Claritin (loratadine) are similar medications, “patients can absolutely have differing responses to Zyrtec and ...
Cetirizine crosses the blood–brain barrier only slightly, and for this reason, produces minimal sedation compared to many other antihistamines. [28] A positron emission tomography (PET) study found that brain occupancy of the H 1 receptor was 12.6% for 10 mg cetirizine, 25.2% for 20 mg cetirizine, and 67.6% for 30 mg hydroxyzine . [ 29 ] (
[22] [27] Subsequently, other non-sedating antihistamines like loratadine (Claritin), cetirizine (Zyrtec), and fexofenadine (Allegra) were developed and introduced. [22] The introduction of the first-generation antihistamines marked the beginning of medical treatment of nasal allergies. [28]
Levocetirizine is an antihistamine. It acts as an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increases the blood supply to the area, providing relief from the typical symptoms of hay fever.
The newer, second-generation H 1-antihistamines are far more selective for peripheral histamine H 1-receptors and have a better tolerability profile compared to the first-generation agents. The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth.
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives . [ 5 ] It is also available in drug combinations such as loratadine/pseudoephedrine , in which it is combined with pseudoephedrine , a nasal decongestant . [ 5 ]
Zyrtec-D, an example of combination therapy. Combination therapy with antihistamines. Antihistamines and decongestants can be used as a combination to treat nasal congestion, runny nose, and sneezing symptoms caused by common cold and hay fever. Some examples include: Pseudoephedrine + Loratadine (Claritin-D®) Pseudoephedrine + Cetirizine
Bilastine is an antihistamine medication used to treat hives (), allergic rhinitis and itchy inflamed eyes (allergic conjunctivitis) caused by an allergy. [6] It is a second-generation antihistamine and takes effect by selectively inhibiting the histamine H 1 receptor, preventing these allergic reactions. [7]
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