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HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system Condition Associated HLA allele(s) Fixed drug eruption: B22 Lichen planus: DR1 DR2 DRw9 DR10 Bw15 B8 Psoriasis: Cw6 DR406 Psoriatic arthritis: B27 Ankylosing spondylitis: B27 Reactive arthritis: B27 Acute anterior uveitis: B27 Behçet ...
The purpose of Ownership Management services, described in chapter 7 of the HLA Interface Specification, [5] is to dynamically manage what federate that simulates what aspect of an object instance. In HLA, only one federate is allowed to update a given attribute of a given object instance. That federate is considered the owner of the attribute.
The American Society for Histocompatibility and Immunogenetics (ASHI) is an American scientific society that was established in 1972. [1] It is responsible for accrediting HLA typing laboratories internationally to maintain the quality standards for histocompatibility testing between donors and recipients, with UNOS and NMDP utilizing its service to inspect and determine whether laboratories ...
Another version of the HLA-B gene, HLA-B53, has been shown to help protect against severe malaria. [4] HLA-B53 is most common in West African populations, where malaria is a frequent cause of death in children. Researchers suggest that this version of the HLA-B gene may help the immune system respond more effectively to the parasite that causes ...
HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR (Human Leukocyte Antigen – DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR).
HLA-NET is a network targeted to the study of Human leukocyte antigen (HLA) from a populational point of view. The network was initiated by COST Action BM0803 [ 1 ] in January 2009. Currently HLA-NET activities are being coordinated by a subcommittee of the scientific committee of the European Federation for Immunogenetics .
HLA research didn't heat up until the 1980s when a group of researchers finally elucidated the shape of the HLA-A*02 protein (just one of many specific HLA proteins). [1] Even more recently, in 2010, the WHO committee responsible for naming all HLA proteins revised their standards for naming to introduce more clarity and specificity in the ...