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Telmisartan, sold under the brand name Micardis among others, is a medication used to treat high blood pressure and heart failure. [ 3 ] [ 6 ] It is a reasonable initial treatment for high blood pressure. [ 6 ]
The transmembrane helices also contribute to the binding via the C-terminal carboxyl group that interacts with Lys 199 in the upper part of helix 5 of the receptor; see figure 1 for details. [8] The ionic bridge formed between Lys 199 and the carboxyl terminal group of the Phe 8 residue of Ang II is most likely stabilized by the Trp 253 residue.
Telmisartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the kidneys' ability to retain water. [2] The combination was approved for medical use in the United States in November 2000, [6] [7] and in the European Union in April 2002.
A study on people who had heart attacks found that those with lower cortisol levels were more likely to develop PTSD. (Cortisol is known as “the stress hormone.”) (Cortisol is known as “the ...
One of the most notable scientific papers that first popularized hydroxychloroquine as a COVID-19 treatment was retracted from its journal due to ethical and methodological issues. Retractions in ...
A 2024 study found that drinking red wine may significantly decrease certain markers of inflammation related to atherosclerosis—plaque buildup on the artery walls. Interestingly, this was true ...
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2] The combination was approved for medical use in the United States in 2009. [2] The combination is on the World Health Organization's List of Essential Medicines.