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[1] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation. [2] Similar to melatonin, 6-OHM is a full agonist of the MT 1 and MT 2 receptors. [3] [4] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin. [5] [6]
6-Hydroxymelatonin (6-OHM) Indorenate This page was last edited on 5 November 2022, at 19:27 ... This page was last edited on 5 November 2022, at 19:27 (UTC).
The bioavailability of melatonin is between 2.5 and 50%. [6] [7] Melatonin is rapidly absorbed and distributed, reaching peak plasma concentrations after 60 minutes of administration, and is then eliminated. [6] Usual doses of exogenous melatonin of 1 to 12 mg produce melatonin concentrations 10 to 100 times higher than endogenous peak levels. [7]
Cyclic 3-hydroxymelatonin (3-OHM) is a metabolite of melatonin and an antioxidant more potent than melatonin. [1] It is a non-radical species and does not further propagate the radical chain reaction It is a footprint product of the reaction between melatonin and hydroxyl radical. [2]
5,6-Dihydroxytryptamine (5,6-DHT) is a monoaminergic neurotoxin and tryptamine derivative related to serotonin (5-hydroxytryptamine) and 5,7-dihydroxytryptamine (5,7-DHT). [ 1 ] [ 2 ] [ 3 ] It is a relatively selective serotonergic neurotoxin , but also acts as a dopaminergic and noradrenergic neurotoxin at higher doses.
BK-NM-AMT, or βk-NM-αMT, also known as β-keto-N-methyl-αMT or as α,N-dimethyl-β-ketotryptamine, is a serotonin–dopamine releasing agent (SDRA) and putative entactogen of the tryptamine, α-alkyltryptamine, and β-ketotryptamine families.
Figure 5 is a more general scheme of the reaction pathway from serotonin to melatonin. The number 2.1.1.4 refers to the Enzyme Commission Number (EC Number) for N- Acetylserotonin O-methyltransferase. These two steps are embedded in the highly involved tryptophan metabolism pathway. [13] Figure 5: Pathway serotonin → melatonin
6-MeO-DMT, or 6-methoxy-N,N-dimethyltryptamine, also known as 6-OMe-DMT, is a serotonergic drug of the tryptamine family. [ 1 ] [ 2 ] It is the 6- methoxy derivative of the serotonergic psychedelic N , N -dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT .