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The enzyme has both primase and polymerase functions in addition to helicase function. The gene coding for it is found in a prophage. [17] It bears homology to ORF904 of plasmid pRN1 from Sulfolobus islandicus, which has an AEP PrimPol domain. [23] Vaccinia virus D5 and HSV Primase are examples of AEP-helicase fusion as well. [12] [6]
The E. Coli DnaG primase is a 581 residue monomeric protein with three functional domains, according to proteolysis studies. There is an N-terminal Zinc-binding domain (residues 1–110) where a zinc ion is tetrahedrally coordinated between one histidine and three cysteine residues, which plays a role in recognizing sequence specific DNA binding sites.
18968 Ensembl ENSG00000101868 ENSMUSG00000006678 UniProt P09884 P33609 RefSeq (mRNA) NM_016937 NM_001330360 NM_001378303 NM_008892 RefSeq (protein) NP_001317289 NP_058633 NP_001365232 NP_032918 Location (UCSC) Chr X: 24.69 – 25 Mb Chr X: 92.35 – 92.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by ...
After α-primase synthesizes the first primers, the primer-template junctions interact with the clamp loader, which loads the sliding clamp onto the DNA to begin DNA synthesis. The components of the preinitiation complex remain associated with replication forks as they move out from the origin.
Along the DNA template, primase intersperses RNA primers that DNA polymerase uses to synthesize DNA from in the 5′→3′ direction. [1] Another example of primers being used to enable DNA synthesis is reverse transcription. Reverse transcriptase is an enzyme that uses a template strand of RNA to synthesize a complementary strand of DNA.
Apple agreed to pay $95 million in cash to settle a proposed class action lawsuit claiming that its voice-activated Siri assistant violated users' privacy. A preliminary settlement was filed on ...
Staying hydrated is one of the most important, if not the most important, things you can do for your overall health. A well-hydrated body can reap improvements in sleep, mood, cognition, digestion ...
WASHINGTON (Reuters) -President-elect Donald Trump cannot ignore a law requiring Chinese-based ByteDance to divest its popular short video app TikTok in the U.S. by early next year or face a ban ...