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HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. [8]
These downstream signaling proteins initiate several signal transduction cascades, principally the MAPK, Akt and JNK pathways, leading to DNA synthesis and cell proliferation. [12] Such proteins modulate phenotypes such as cell migration, adhesion, and proliferation. Activation of the receptor is important for the innate immune response in ...
The HER2 pathway promotes cell growth and division when it is functioning normally; however, when it is overexpressed, cell growth accelerates beyond its normal limits. In some types of cancer, the pathway is exploited to promote rapid cell growth and proliferation and hence tumor formation. [59]
107221 Ensembl ENSG00000186188 ENSMUSG00000054200 UniProt Q5NUL3 Q7TMA4 RefSeq (mRNA) NM_001195755 NM_181745 NM_181748 RefSeq (protein) NP_001182684 NP_859529 NP_861413 Location (UCSC) Chr 10: 93.57 – 93.6 Mb Chr 19: 38.09 – 38.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein ...
The PI3K/AKT pathway is crucial in this decision making process. NSCs are able to sense and respond to changes in the brain or throughout the organism. When blood glucose levels are elevated acutely, insulin is released from the pancreas. Activation of insulin receptors activates the PI3K/AKT pathway, which promotes proliferation. [3]
The benefits of walking abound—improving heart health, sleep quality, and mood are just a few of the many pros of going for a stroll. Now, new research has found that walking could add over 10 ...
What I liked about Storyworth. There’s a lot to like about Storyworth, assuming you either choose to answer the questions yourself or choose to pepper a willing participant.
In the words of Nikolay Kukushkin, a clinical associate professor of life science at New York University, “A food coma is a behavioral response to eating food when the animal, whether it's human ...
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