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The Robo proteins are critical regulators of midline crossing across species. In Drosophila embryos, Robo1 and Robo2 are required to keep ipsilaterally projecting axons from inappropriately crossing the midline, and to prevent contralateral axons from remaining stuck at the midline. Robo3, while it also binds Slit, does not appear to play a ...
Passes toy to other hand when offered a second object (referred to as "crossing the midline" – an important neurological development). Manages three to four objects by setting an object aside (on lap or floor) when presented with a new toy. Puts toys in mouth less often. Enjoys looking at picture books.
Comm expression turns off after the growth cone has crossed the midline; this permits Robo/Slit repulsion and prevents the growth cone from crossing the midline again. Vertebrates, on the other hand, do not possess a comm homolog ; instead they facilitate midline crossing through alternative splicing of Robo3 (aka.Rig-1).
The main function of Slit proteins is to act as midline repellents, preventing the crossing of longitudinal axons through the midline of the central nervous system of most bilaterian animal species, including mice, chickens, humans, insects, nematode worms and planarians. [3] It also prevents the recrossing of commissural axons.
A new study says that exhaust from gasoline containing lead may have contributed to ADHD, anxiety, and other mental health disorders in a large segment of the population
The inability of these axons to cross the midline results in anomalous axonal guidance and front-to-back projections within each hemisphere, rather than connecting between the hemispheres in the normal corpus callosum. These longitudinal callosal fascicles were originally described by Moriz Probst in 1901 by gross anatomical observation. [1]
By that reasoning, Miami’s playoff hopes are toast barring an unexpected blowout loss for a team like Penn State or Georgia in their conference title games on Saturday that somehow drops one or ...
From July 2011 to December 2012, if you bought shares in companies when Elaine L. Chao joined the board, and sold them when she left, you would have a 19.2 percent return on your investment, compared to a 6.5 percent return from the S&P 500.
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