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The 1933 Road Map of Mississippi shows MS 25 running northward from Macon roughly along the 2019 alignment of U.S. Route 45 to Brooksville, then roughly along the 2019 alignment of U.S. Route 45 Alternate through Artesia and West Point to Muldon, where the 2019 alignment continues in a northeasterly direction.
Major junctions of U.S. 45 in Mississippi include U.S. Route 84 at Waynesboro, Interstate 20/59 at Meridian, U.S. Route 82 at Columbus, Interstate 22/U.S. Route 78 at Tupelo and U.S. Route 72 at Corinth. Each of these junctions is an interchange and, with the exception of Columbus and Waynesboro, each is part of a freeway segment.
I-22/US 78 then enters Lee County and passes north of Tupelo, its county seat, with five exits (81, 82, 85, 86, and 87) connecting to the city, including an interchange with MS 178 (exit 81) northwest of Tupelo along with interchanges with the Natchez Trace Parkway (exit 85) and US 45/Corridor V (exit 86) north of the city with Corridor V ...
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Tupelo (/ ˈ t uː p ə l oʊ / TOO-pə-loh) is a city in and the county seat of Lee County, Mississippi, United States. Founded in 1860, [ 4 ] the population was 37,923 at the 2020 census . It is the 7th most populous city in Mississippi and is considered a commercial, industrial, and cultural hub of northern Mississippi .
MS 6/US 278 at their interchange with US 45 in Tupelo. MS 6 turns left along Main Street to leave Nettleton and head southeast through wooded areas (as it enters the Appalachian Mountains foothills) for several miles, where it has intersections with Old Highway 6 (unsigned MS 776) and MS 371, to pass through Bigbee.
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas, to Charleston, South Carolina.From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22).
Main Street – Tupelo, Pontotoc, Tupelo National Battlefield: Two-quadrant interchange: 261: 420: Chickasaw Village Site: 262: 422: MS 178 (McCullough Boulevard) – Elvis Presley Birthplace: Two-quadrant interchange: 263: 423: I-22 / US 78 – Tupelo, Fulton, New Albany, Tombigbee State Park, Elvis Presley Lake: Partial cloverleaf interchange ...
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