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High levels of LDL, cholesterol, or triglycerides can cause peripheral artery disease, in which the arteries that carry blood to your legs can narrow or become blocked. You might notice pain or ...
High levels of LDL, cholesterol, or triglycerides can cause peripheral artery disease, in which the arteries that carry blood to your legs can narrow or become blocked. You might notice pain or ...
Statins reduce high levels of LDL particles by inhibiting the enzyme HMG-CoA reductase in cells, the rate-limiting step of cholesterol synthesis. To compensate for the decreased cholesterol availability, synthesis of LDL receptors (including hepatic) is increased, resulting in an increased clearance of LDL particles from the extracellular water ...
LDL cholesterol is the “bad” cholesterol that can increase the risk of heart disease and stroke when levels are too high. HDL cholesterol is “good” cholesterol and high levels of it can ...
LDL cholesterol is produced naturally by the body, but eating a diet high in saturated fat, trans fats, and cholesterol can increase LDL levels. [43] Elevated LDL levels are associated with diabetes, hypertension, hypertriglyceridemia, and atherosclerosis. In a fasting lipid panel, a LDL greater than 160 mg/dL is abnormal. [37] [39]
Levels of LDL or non-HDL cholesterol both predict future coronary heart disease; which is the better predictor is disputed. [39] High levels of small dense LDL may be particularly adverse, although measurement of small dense LDL is not advocated for risk prediction. [39] In the past, LDL and VLDL levels were rarely measured directly due to cost.
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