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  2. Cellular senescence - Wikipedia

    en.wikipedia.org/wiki/Cellular_senescence

    The phosphorylation cascade initiated by these two kinases causes the eventual arrest of the cell cycle. Depending on the severity of the DNA damage, the cells may no longer be able to undergo repair and either go through apoptosis or cell senescence. [8] Such senescent cells in mammalian culture and tissues retain DSBs and DDR markers. [14]

  3. Hallmarks of aging - Wikipedia

    en.wikipedia.org/wiki/Hallmarks_of_aging

    The links between cell senescence and aging are several: The proportion of senescent cells increases with age. [40] Senescent cells secrete inflammatory markers which may contribute to aging. [41] Clearance of senescent cells has been found to delay the onset of age-related disorders. [42]

  4. Senescence - Wikipedia

    en.wikipedia.org/wiki/Senescence

    Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle.

  5. Limbic-predominant age-related TDP-43 encephalopathy

    en.wikipedia.org/wiki/Limbic-predominant_age...

    LATE is a term that describes a prevalent medical condition with impaired memory and thinking in advanced age, often culminating in the dementia clinical syndrome. [1] In other words, the symptoms of LATE are similar to those of Alzheimer's disease. The acronym LATE stands for Limbic-predominant Age-related TDP-43 Encephalopathy.

  6. Immunosenescence - Wikipedia

    en.wikipedia.org/wiki/Immunosenescence

    T cells' functional capacity is most influenced by aging effects. Age-related alterations are evident in all T-cell development stages, making them a significant factor in immunosenescence. [27] T-cell function decline begins with the progressive involution of the thymus, which is the organ essential

  7. Reversing your biological age could help you live longer—and ...

    www.aol.com/finance/reversing-biological-age...

    A higher red blood cell count seems to denote an increased risk of dementia. Women below the age of 60 with an elevated biological age appear to be at the greatest risk of developing dementia ...

  8. Vitamin B12 deficiency symptoms - AOL

    www.aol.com/finance/vitamin-deficiency-cause...

    About 5.8 million people in the U.S. have Alzheimer's disease and related dementias, giving these life-altering illnesses a wide impact across the country. But while it can be devastating when a ...

  9. Biological immortality - Wikipedia

    en.wikipedia.org/wiki/Biological_immortality

    Biological immortality (sometimes referred to as bio-indefinite mortality) is a state in which the rate of mortality from senescence (or aging) is stable or decreasing, thus decoupling it from chronological age. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or ...

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