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The mixture of cannabinoids produced by a plant is known as the plant's cannabinoid profile. Selective breeding has been used to control the genetics of plants and modify the cannabinoid profile. For example, strains that are used as fiber (commonly called hemp) are bred such that they
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
Cannabinoids and their K i values [a] Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x) JWH-007 [5] Naphthoylindole: 9.5 ± 4.5: 2.9 ± 2.6: CB 2 (3.3x) JWH-009: Naphthoylindole >10000: 141 ± 14: CB 2 (>70x) JWH-011: Naphthoylindole: JWH-015 [5] Naphthoylindole: 164 ± ...
CBN, as one of the many phytocannabinoids derived from Cannabis Sativa L, is considered a classical cannabinoid. Other examples of compounds in this group include dibenzopyran derivatives such as Δ 9-THC, well-known for underlying the subjective "high" experienced by cannabis users, as well as Δ 8-THC, and their
Example of a container and the recreational cannabis purchase in Canada. Medical cannabis, or medical marijuana, refers to the use of cannabis to treat disease or improve symptoms; however, there is no single agreed-upon definition (e.g., cannabinoids derived from cannabis and synthetic cannabinoids are also used).
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
The cannabis plant contains more than 100 cannabinoids, including THC and CBD, and hundreds of non-cannabinoid chemicals. Scientists are just beginning to understand the effect these compounds ...
Similar enzymes to THCA synthase catalyze the formation of other cannabinoids. For example, cannabidiolic acid (CBDA) synthase is a flavoprotein that catalyzes a similar oxidative cyclization of CPGA into CBDA, the dominant cannabinoid constituent of fiber-type C. sativa. CBDA undergoes a similar decarboxylation to form cannabidiol. [12]