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The first step in drug discovery is often measurement of the MICs of biological extracts, isolated compounds or large chemical libraries against bacteria and fungi of interest. [9] [10] MIC values provide a quantitative measure of an extract or compound's antimicrobial potency. The lower the MIC, the more potent the antimicrobial. [4]
To create the solution, 11.6 g NaCl is placed in a volumetric flask, dissolved in some water, then followed by the addition of more water until the total volume reaches 100 mL. The density of water is approximately 1000 g/L and its molar mass is 18.02 g/mol (or 1/18.02 = 0.055 mol/g). Therefore, the molar concentration of water is
The definition of a w is where p is the partial water vapor pressure in equilibrium with the solution, and p* is the (partial) vapor pressure of pure water at the same temperature. An alternate definition can be a w ≡ l w x w {\displaystyle a_{w}\equiv l_{w}x_{w}} where l w is the activity coefficient of water and x w is the mole fraction of ...
Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1]
The following formulas can be used to calculate the volumes of solute (V solute) and solvent (V solvent) to be used: [1] = = where V total is the desired total volume, and F is the desired dilution factor number (the number in the position of F if expressed as "1/F dilution factor" or "xF dilution"). However, some solutions and mixtures take up ...
Multivitamins nutrition facts label showing that the international unit of, for example, vitamins D and E correspond to different gram values. In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances.
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Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are related, they are not the same thing.