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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
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DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
And feel free to store any extra brownies in the fridge for up to 7 days. View Recipe. Almond Confetti Mandel Bread. ... Winter Storm Blair live updates: Blizzard warning extended into Kansas City.
Jennifer Kaye Ringley (born August 10, 1976) [1] is an Internet personality and former lifecaster. She is widely regarded as the first camgirl. She is known for creating the popular website JenniCam. [2] [3] Previously, live webcams transmitted static shots from cameras aimed through windows or at coffee pots. [4]
Add solar superflares to the list of natural disasters of concern. Superflares are extremely strong solar flares – explosions with energies up to ten thousand times that of typical solar flares.
How To Make My 3-Ingredient Macaroons. For about 24 macaroons, you’ll need: 4 large egg whites. 1/2 cup (100 grams) granulated sugar. 1 1/2 teaspoons vanilla extract, optional