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In case of established cancerous dissemination it is postulated that the sentinel lymph nodes are the target organs primarily reached by metastasizing cancer cells from the tumor. The sentinel node procedure (also termed sentinel lymph node biopsy or SLNB) is the identification, removal and analysis of the sentinel lymph nodes of a particular ...
CP-GEP is a non-invasive prediction model for cutaneous melanoma patients that combines clinicopathologic (CP) variables with gene expression profiling (GEP). CP-GEP is able to identify cutaneous melanoma patients at low-risk for nodal metastasis who may forgo the sentinel lymph node biopsy (SLNB) procedure.
Sentinel lymph node biopsy is the analysis of a few removed sentinel nodes for the presence of cancerous cells. A radioactive substance is used to dye the sentinel nodes for easy identification and removal. [2] If cancer is detected in the sentinel node then further treatment is needed.
Virchow's nodes take their supply from lymph vessels in the abdominal cavity, and are therefore sentinel lymph nodes of cancer in the abdomen, particularly gastric cancer, ovarian cancer, testicular cancer and kidney cancer, that has spread through the lymph vessels, and Hodgkin's lymphoma. [1]
To locate the draining lymph nodes or sentinel lymph nodes from a breast cancer tumour, a Technetium-99m based radiopharmaceutical is common. This may be a nanocolloid or sestamibi . [ 7 ] Although imaging with a gamma camera may also take place, the idea of a small gamma probe is that it can be used to identify lymph nodes (or other sites ...
Indocyanine green (ICG) has been widely used as a non-specific agent to detect sentinel lymph nodes during surgery. [12] ICG has the main advantage of absorbing and emitting light in the near infrared, [3] allowing detection of nodes under several centimeters of tissue.
Melanoma metastasizes early into regional lymph nodes, so excision and analysis of so-called sentinel lymph nodes is important for treatment planning and prognosis assessment. To identify the sentinel lymph node for excision, a gamma-emitting radiotracer is injected inside the primary tumor and allowed to accumulate inside the sentinel lymph node.
This page was last edited on 11 February 2014, at 20:22 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
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