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Pernicious anemia often presents slowly, and can cause harm insidiously and unnoticeably. Untreated, it can lead to neurological complications, and in serious cases, death. [19] The onset may be vague and slow and the condition can be confused with other conditions, and there may be few to many symptoms without anemia. [20]
As an example, calcium in excess can cause bone problems, especially in the large-breed dogs. Over-supplementation of vitamins A and D can cause vitamin toxicity in dogs. [ 72 ] Excess vitamin A can cause dehydration , joint pain and can also harm the blood vessels , while too much vitamin D can cause muscular atrophy , loss of appetite and ...
Its deficiency can cause neurodevelopmental problems which can be partly reversible with early treatment. [27] Only a small subset of dementia cases have been found to be reversible with vitamin B 12 therapy. [28] Tinnitus may be associated with vitamin B 12 deficiency. [29] Vitamin B 12 deficiency may accompany certain eating disorders or ...
Cyanocobalamin is a form of vitamin B 12 used to treat and prevent vitamin B 12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer.
B12 also tamps down chronic inflammation within the cardiovascular system (that can, in turn, lower heart disease risk), helps maintain the nervous system (including the myelin sheath ...
A second major cause is an age-related decline in stomach acid production (achlorhydria), because acid exposure frees protein-bound vitamin. [12] For the same reason, people on long-term antacid therapy, using proton-pump inhibitors , [ 13 ] H 2 blockers or other antacids are at increased risk.
Atrophic gastritis can also cause intrinsic factor deficiency and anemia through damage to the parietal cells of the stomach wall. [16] Pancreatic exocrine insufficiency can interfere with normal dissociation of vitamin B 12 from its binding proteins in the small intestine, preventing its absorption via the intrinsic factor complex. [ 17 ]
Autoimmune disorders are also a cause for small bacterial growth in the bowel and a deficiency of Vitamin B-12. These have also proved to be factors of acid secretion in the stomach. [7] Autoimmune conditions can often be managed with various treatments; however, little is known about how or if these treatments effect achlorhydria. [5]
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