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Since the first description of cryoglobulinemia in association with the clinical triad of skin purpura, joint pain, and weakness by Meltzer et al. in 1966, [4] [5] the percentage of cryoglobulinemic diseases described as essential cryoglobulinemia or idiopathic cryoglobulinemia (that is, cryoglobulinemic disease that is unassociated with an underlying disorder) has fallen.
Cryoglobulinemic vasculitis is a form of inflammation affecting the blood vessels caused by the deposition of abnormal proteins called cryoglobulins.These immunoglobulin proteins are soluble at normal body temperatures, but become insoluble below 37 °C (98.6 °F) and subsequently may aggregate within smaller blood vessels.
Cryofibrinogenemia refers to a condition classified as a fibrinogen disorder in which a person's blood plasma is allowed to cool substantially (i.e. from its normal temperature of 37 °C to the near-freezing temperature of 4 °C), causing the (reversible) precipitation of a complex containing fibrinogen, fibrin, fibronectin, and, occasionally, small amounts of fibrin split products, albumin ...
Hyperviscosity and/or thrombosis are the principal signs and symptoms of type I cryoglobulinemia. As a result, the conditions most frequently manifested as Raynaud's phenomenon , distal gangrene , ischemic ulcers, purpura , livedo reticularis , headache , retinal hemorrhages, and encephalopathy .
Iron deficiency anemia can intensify symptoms of fatigue and shortening of breath, and can cause cold sensitivity, hair loss, paleness to the skin and nail changes, says Cunningham. It has also ...
For children, the FDA has approved the use of synthetic HGH to treat growth hormone deficiency (GHD), being born small for gestational age, idiopathic short stature, chronic renal insufficiency ...
Cold sensitive antibodies (CSA) are antibodies sensitive to cold temperature. Some cold sensitive antibodies are pathological and can lead to blood disorder.These pathological cold sensitive antibodies include cold agglutinins, Donath–Landsteiner antibodies, and cryoglobulins which are the culprits of cold agglutinin disease, paroxysmal cold hemoglobinuria in the process of Donath ...
CNN: What symptoms should people expect and for how long? Wen: Symptoms of norovirus include nausea, vomiting, diarrhea and stomach cramps. Some people may also experience fatigue, low-grade fever ...