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The metaphysis (pl.: metaphyses) is the neck portion of a long bone between the epiphysis and the diaphysis. [1] It contains the growth plate , the part of the bone that grows during childhood, and as it grows it ossifies near the diaphysis and the epiphyses.
Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. [ 1 ]
The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components.
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length).
The outer shell of the long bone is made of cortical bone also known as compact bone. [1] This is covered by a membrane of connective tissue called the periosteum.Beneath the cortical bone layer is a layer of spongy cancellous bone.
Mesenchymal stem cells within mesenchyme or the medullary cavity of a bone fracture initiate the process of intramembranous ossification. A mesenchymal stem cell, or MSC, is an unspecialized cell that can develop into an osteoblast.
Together with rhizomelic limb shortening, the presence of epiphyseal-metaphyseal changes of the long bones is a distinctive radiologic feature of pseudoachondroplasia. Hypoplastic capital femoral epiphyses, broad short femoral necks, coxa vara, horizontality of acetabular roof and delayed eruption of secondary ossification center of os pubis ...
Popcorn calcification or popcorn appearance is the radiological appearance of calcification with irregular rings and arcs, which resembles popcorns.The calcification patterns in chondroid lesions of the bone (such as enchondroma and chondrosarcoma), [1] pulmonary hamartomas, [2] degenerating fibroadenomas of the breast and calcified fibroids of the uterus have been described as 'popcorn ...
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