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Another important cause of aortic stenosis is chronic rheumatic fever, which can cause repeated inflammation and repair, leading to fibrosis. In this case, the leaflets can actually fuse together, called commissural fusion, which can be an important distinction from the type caused by mechanical stress over time.
The standard for diagnosis of aortic stenosis is non-invasive testing with echocardiography. Cardiac catheterization is reserved for cases in which there is a discrepancy between the clinical picture and non-invasive testing, due to risks inherent to crossing the aortic valve, such as stroke. [7]
In patients with non-severe asymptomatic aortic valve stenosis, increased age- and sex adjusted N-terminal pro-brain natriuretic peptide levels alone and combined with a 50% or greater increase from baseline had been found associated with increased event rates of aortic valve stenosis related events (cardiovascular death, hospitalization with ...
Aortic stenosis can also be caused by rheumatic fever and degenerative calcification. [7] The most common congenital heart defect is the bicuspid aortic valve (fusion of two cusps together) commonly found in Turner syndrome .
In some parts of the world rheumatic heart disease is a major cause of valvular heart disease, typically leading to mitral or aortic stenosis and caused by the body's immune system reacting to a streptococcal throat infection. [60] [61]
Rheumatic fever can be prevented by effectively and promptly treating strep throat with antibiotics. [45] Globally, rheumatic fever is seen in populations that are socioeconomically disadvantaged and with limited access to health care. [46] Overcrowding [46] [47] and exposure to domestic air pollution [47] have been cited as associated risk ...
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