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Depression and Anxiety is a monthly peer-reviewed medical journal published by Wiley-Blackwell.It is an official journal of the Anxiety and Depression Association of America and covers research on depressive and anxiety disorders.
The symptoms of anxiety and depression disorders can be very similar. A diagnosis of mixed anxiety–depressive disorder as opposed to a diagnosis of depression or an anxiety disorder can be difficult. Due to this, it has long been a struggle to find a singular set of criteria to use in the diagnosis of mixed-anxiety depressive disorder. [3]
Depressive anxiety is a term developed in relation to the depressive position by Melanie Klein, building on Freud's seminal article on object relations of 1917, 'Mourning and Melancholia'. [1] Depressive anxiety revolved around a felt state of inner danger produced by the fear of having harmed good internal objects [ 2 ] - as opposed to the ...
The ability to distinguish between anxiety and depression with this model may help increase diagnostic accuracy and help eliminate the complications that occur with comorbidity. [ 4 ] [ 5 ] According to Clark, depressed patients have a comorbidity rate of 57% for any anxiety disorder. [ 6 ]
This proposed subtype is characterized by depression occurring as a consequence of psychic, somatic or external stressors. Praag theorizes that if the individual's stress threshold is insufficient or overly sensitive, a prolonged stress response via the HPA axis can trigger anxiety followed by significant lowering of mood, the mechanisms of which act to reenforce each other, keeping them a ...
Suberoylanilide hydroxamic acid significantly reversed anxiety-like behaviors and stress-induced gastrointestinal hypersensitivity and fecal pellet output. [93] Anxiety-like and depression-like behaviors caused by immobilization stress or nicotine addiction were also reduced in mice treated with the HDACi sodium butyrate and valproic acid. [94]
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