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2. Bone marrow failure - Wikipedia

   en.wikipedia.org/wiki/Bone_marrow_failure

   For those with severe bone marrow failure, the cumulative incidence of resulting stem cell transplantation or death was greater than 70% by individuals 60 years of age. [13] The incidence of bone marrow failure is triphasic: one peak at two to five years during childhood (due to inherited causes), and two peaks in adulthood, between 20 and 25 ...

3. Hematopoietic stem cell transplantation - Wikipedia

   en.wikipedia.org/wiki/Hematopoietic_stem_cell...

   Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...

4. Gene therapy for blood diseases - Wikipedia

   en.wikipedia.org/wiki/Gene_therapy_for_blood...

   Patients in the U.S. suffering from sickle cell disease can now receive targeted gene therapies using hematopoietic stem cells. [6] Hematopoietic stem cells are stem cells which differentiate and give rise to red blood cells, white blood cells and platelets. [7] These therapies involve removing hematopoietic stem cells from the patient and ...

5. Stem cell theory of aging - Wikipedia

   en.wikipedia.org/wiki/Stem_cell_theory_of_aging

   The cellularity of the bone marrow does decrease with age and can be usually calculated by the formula 100-age, and this seems consistent with a stem cell theory of aging. [18] A dog study published by Zaucha J.M, Yu C. and Mathioudakis G., et al. also shows evidence against the stem cell theory. Experimental comparison of the engraftment ...

6. Stem-cell therapy - Wikipedia

   en.wikipedia.org/wiki/Stem-cell_therapy

   Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.

7. Hematopoietic stem cell - Wikipedia

   en.wikipedia.org/wiki/Hematopoietic_stem_cell

   Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [ 16 ] [ 17 ] [ 13 ] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an ...