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In genetics, a three-point cross is used to determine the loci of three genes in an organism's genome.. An individual heterozygous for three mutations is crossed with a homozygous recessive individual, and the phenotypes of the progeny are scored.
In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
Gene order is the permutation of genome arrangement. A fair amount of research has been done trying to determine whether gene orders evolve according to a molecular clock (molecular clock hypothesis) or in jumps (punctuated equilibrium). By comparing gene orders in dissimilar organisms, scientists are able to develop a molecular phylogeny tree. [1]
A point on both parents' chromosomes is picked randomly, and designated a 'crossover point'. Bits to the right of that point are swapped between the two parent chromosomes. This results in two offspring, each carrying some genetic information from both parents.
The linked frequency of crossing over between two gene loci is the crossing-over value. For fixed set of genetic and environmental conditions, recombination in a particular region of a linkage structure tends to be constant and the same is then true for the crossing-over value which is used in the production of genetic maps.
Ab Initio gene prediction is an intrinsic method based on gene content and signal detection. Because of the inherent expense and difficulty in obtaining extrinsic evidence for many genes, it is also necessary to resort to ab initio gene finding, in which the genomic DNA sequence alone is systematically searched for certain tell-tale signs of protein-coding genes.
In a test cross, the individual in question is bred with another individual that is homozygous for the recessive trait and the offspring of the test cross are examined. [2] Since the homozygous recessive individual can only pass on recessive alleles, the allele the individual in question passes on determines the phenotype of the offspring. [3]
Coalescent theory is a model of how alleles sampled from a population may have originated from a common ancestor.In the simplest case, coalescent theory assumes no recombination, no natural selection, and no gene flow or population structure, meaning that each variant is equally likely to have been passed from one generation to the next.