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  2. Allopurinol - Wikipedia

    en.wikipedia.org/wiki/Allopurinol

    Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...

  3. Acceptable daily intake - Wikipedia

    en.wikipedia.org/wiki/Acceptable_Daily_Intake

    For instance, if the ADI is based on data from humans the safety factor is usually 10 instead of 100. The ADI is usually given in mg per kg body weight. [5] The ADI is considered a safe intake level for a healthy adult of normal weight who consumes an average daily amount of the substance in question.

  4. Allopurinol hypersensitivity syndrome - Wikipedia

    en.wikipedia.org/wiki/Allopurinol...

    Allopurinol hypersensitivity syndrome (AHS) typically occurs in persons with preexisting kidney failure. [3]: 119 Weeks to months after allopurinol is begun, the patient develops a morbilliform eruption [3]: 119 or, less commonly, develops one of the far more serious and potentially lethal severe cutaneous adverse reactions viz., the DRESS syndrome, Stevens Johnson syndrome, or toxic epidermal ...

  5. Defined daily dose - Wikipedia

    en.wikipedia.org/wiki/Defined_Daily_Dose

    At the time, the RDD of rosuvastatin was similar to its DDD (12.6 mg vs 10mg), but the RDD of atorvastatin was twice its DDD (20.6 mg vs 10mg). The DDD of atorvastatin was revised in 2009 to 20mg. [4] The Canadian Patented Medicine Prices Review Board analysed the use of DDD for drug utilisation and cost analysis and offered recommendations ...

  6. Febuxostat - Wikipedia

    en.wikipedia.org/wiki/Febuxostat

    In the UK, NICE has found that febuxostat has a higher cost/benefit ratio than allopurinol and on that basis recommended febuxostat as a second-line drug for people who cannot use allopurinol. [12] In 2010, before it became generic in the United States, it cost about US$160 per month as opposed to allopurinol which was about $14 per month. [31]

  7. Lesinurad/allopurinol - Wikipedia

    en.wikipedia.org/wiki/Lesinurad/allopurinol

    Lesinurad/allopurinol (trade name Duzallo) is a fixed-dose combination drug for the treatment of gout. [1] It contains 200 mg of lesinurad and 300 mg of allopurinol.In August 2017, the US Food and Drug Administration approved it for the treatment of hyperuricemia associated with gout in patients for whom target serum uric acid levels have not been achieved with allopurinol alone. [2]

  8. Antibiotic use in livestock - Wikipedia

    en.wikipedia.org/wiki/Antibiotic_use_in_livestock

    A CDC infographic on how antibiotic-resistant bacteria have the potential to spread from farm animals. The use of antibiotics in the husbandry of livestock includes treatment when ill (therapeutic), treatment of a group of animals when at least one is diagnosed with clinical infection (metaphylaxis [1]), and preventative treatment (prophylaxis).

  9. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    the dose at which toxicity occurs in 50% of cases. LD Lethal Dose the dose at which death occurs in 50% of cases. [6]: 73 [7] [8] TI Therapeutic Index a quantitative measurement of the relative safety of a drug by comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect [1]

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