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The controversy surrounding the safety of MSG started with the publication of Robert Ho Man Kwok's correspondence letter titled "Chinese-Restaurant Syndrome" in the New England Journal of Medicine on 4 April 1968. [22] [23] In his letter, Kwok suggested several possible causes for symptoms that he experienced before he nominated MSG.
The median lethal dose (LD 50) is between 15 and 18 g/kg body weight in rats and mice, respectively, five times the LD 50 of table salt (3 g/kg in rats). The use of MSG as a food additive and the natural levels of glutamic acid in foods are not of toxic concern in humans. [ 20 ]
Over time, insomnia can take a serious toll. That is especially the case for brain health , both Tiani and Sklar stress. While depression and anxiety can lead to insomnia, losing sleep can ...
A new study reveals a shocking potential cause for insomnia.
Insomnia can be grouped into primary and secondary, or comorbid, insomnia. [124] [125] [126] Primary insomnia is a sleep disorder not attributable to a medical, psychiatric, or environmental cause. [127] There are three main types of primary insomnia.
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Insomnia disorder (primary insomnia), chronic difficulty in falling asleep or maintaining sleep when no other cause is found for these symptoms. Insomnia can also be comorbid with or secondary to other disorders. Kleine–Levin syndrome, a rare disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. [84]
EDS can affect the ability to function in family, social, occupational, or other settings. [1] [2] A proper diagnosis of the underlying cause and ultimately treatment of symptoms and/or the underlying cause can help mitigate such complications. [3] According to the National Sleep Foundation, around 20 percent of people experience EDS. [4]
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