Search results
Results from the WOW.Com Content Network
4-Dimethylaminopyridine (DMAP) is a derivative of pyridine with the chemical formula (CH 3) 2 NC 5 H 4 N. This white solid is of interest because it is more basic than pyridine , owing to the resonance stabilisation from the NMe 2 substituent.
DMAP may refer to: Digital Media Access Protocol, a family of proprietary protocols by Apple; 4-Dimethylaminopyridine (CH 3) 2 NC 5 H 4 N), a derivative of pyridine; 4-Dimethylaminophenol (C 8 H 11 NO), an aromatic compound containing both phenol and amine functional groups; Data Management Advisory Panel, of the England school census
The regulation of DAMP signaling can be a potential therapeutic target to reduce inflammation and treat diseases. For example, administration of neutralizing HMGB1 antibodies or truncated HMGB1-derived A-box protein ameliorated arthritis in collagen-induced arthritis rodent models. Clinical trials with HSP inhibitors have also been reported.
The reactivity of anhydrides can be increased by using a catalytic amount of N,N-dimethylaminopyridine ("DMAP") or even pyridine. [12] First, DMAP (2) attacks the anhydride (1) to form a tetrahedral intermediate, which collapses to eliminate a carboxylate ion to give amide 3. This intermediate amide is more activated towards nucleophilic attack ...
The Yamaguchi esterification is the chemical reaction of an aliphatic carboxylic acid and 2,4,6-trichlorobenzoyl chloride (TCBC, Yamaguchi reagent) to form a mixed anhydride which, upon reaction with an alcohol in the presence of stoichiometric amount of DMAP, produces the desired ester. It was first reported by Masaru Yamaguchi et al. in 1979 ...
Add the amine to di-tert-butyl dicarbonate, 4-dimethylaminopyridine (DMAP), and acetonitrile (MeCN) at ambient temperature [15] BOC-protected amines are prepared using the reagent di-tert-butyl-iminodicarboxylate. Upon deprotonation, this reagent affords a doubly BOC-protected source of NH − 2, which can be N-alkylated.
The reaction mechanism is described as follows: . With amines, the reaction proceeds without problems to the corresponding amides because amines are more nucleophilic.If the esterification is slow, a side-reaction occurs, diminishing the final yield or complicating purification of the product.
Dimethylallyl pyrophosphate (DMAPP; or alternatively, dimethylallyl diphosphate (DMADP); also isoprenyl pyrophosphate) is an isoprenoid precursor.It is a product of both the mevalonate pathway and the MEP pathway of isoprenoid precursor biosynthesis.