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Heterophile antibodies are IgM antibodies with affinity for sheep and horse red blood cells. They appear during the first week of infectious mononucleosis symptoms, 3–4 weeks after infection and return to undetectable levels 3 to 6 months after infection. Heterophile antibody is a fairly specific but insensitive test for EBV.
The mononuclear spot test or monospot test, a form of the heterophile antibody test, [1] is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV). It is an improvement on the Paul–Bunnell test. [2] The test is specific for heterophile antibodies produced by the human immune system in response to EBV
Anti-core antibodies (anti-HBc) are the first antibodies produced by the body, first in short-term IgM (anti-HBc IgM), and subsequently in long-term IgG; while levels of IgM anti-HBc will peak around sixteen weeks after exposure and fall within about seven to eight months, [63] [64] IgG anti-HBc will remain detectable in the serum as a sign of ...
Tests based on monoclonal antibodies and immunofluorescence, including T. pallidum hemagglutination assay and fluorescent treponemal antibody absorption are more specific and more expensive. Nontreponemal tests (NTT) measure levels of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies produced by the host in response to lipoidal ...
Herpes simplex virus 1 (cold sores) and 2 (genital herpes) (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. [1] [2] Both HSV-1 and HSV-2 are very common and ...
The direct Coombs test detects antibodies that are stuck to the surface of the red blood cells. [1] Since these antibodies sometimes destroy red blood cells they can cause anemia; this test can help clarify the condition. The indirect Coombs test detects antibodies that are floating freely in the blood. [1]
Between the ages of 40 and 44, 54.7% of men, 88.7% of women, and 69.2% of pregnant women tested positive for HSV-1 antibodies. The overall age-gender standardized seroprevelance for HSV-1 antibodies was 51.1%. [20] Teenagers are less likely to be seropositive for HSV-2—antibodies against this virus are only found in 0–3.8% of 15- and 16 ...
HSV-1 neonatal herpes is extremely rare in developing countries because development of HSV-1 specific antibodies usually occurs in childhood or adolescence, precluding a later genital HSV-1 infection. HSV-2 infections are much more common in these countries. In industrialized nations, the adolescent HSV-1 seroprevalence has been dropping ...
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