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Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system (CNS). [1] Microglia account for about 10–15% of cells found within the brain. [ 2 ] As the resident macrophage cells, they act as the first and main form of active immune defense in the CNS. [ 3 ]
The cerebellum ("little brain") is a structure located at the rear of the brain, near the spinal cord. It looks like a miniature version of the cerebral cortex, in that it has a wavy, or convoluted surface. [3]
Oligodendrocytes are found exclusively in the CNS, which comprises the brain and spinal cord. They are the most widespread cell lineage, including oligodendrocyte progenitor cells, pre-myelinating cells, and mature myelinating oligodendrocytes in the CNS white matter. [3] Non-myelinating oligodendrocytes are found in the grey matter surrounding ...
Glial cells make up about half the total volume of the brain and spinal cord. [27] The glia to neuron-ratio varies from one part of the brain to another. The glia to neuron-ratio in the cerebral cortex is 3.72 (60.84 billion glia (72%); 16.34 billion neurons), while that of the cerebellum is only 0.23 (16.04 billion glia; 69.03 billion neurons).
The three meninges, membranes that envelop the brain and spinal cord, are composed of connective tissue. Most types of connective tissue consists of three main components: elastic and collagen fibers, ground substance, and cells. [2] Blood, and lymph are classed as specialized fluid connective tissues that do not contain fiber.
After entering a lymph node, they then enter a lymphoid follicle, where they multiply and divide, each producing a different antibody. If a cell is stimulated, it will go on to produce more antibodies (a plasma cell) or act as a memory cell to help the body fight future infection. [25] If a cell is not stimulated, it will undergo apoptosis and ...
Using lymphatic endothelial cell-specific markers and electron microscopy, the authors found that the immune cells were not inside blood vessels, but rather were organized inside lymphatic vessels within the meninges, a system of membranes that envelop the brain and spinal cord. [1]
IgM: Memory B cells that express IgM can be found concentrated in the tonsils, Peyer's patch, and lymph nodes. [3] This subset of memory B cells is more likely to proliferate and reenter the germinal center during a secondary immune response. [4] IgG: Memory B cells that express IgG typically differentiate into plasma cells. [4]